REQUEST FOR PROPOSAL

RFP 14854 – GLP COMPLIANT TOXICOLOGY STUDIES IN THE DOG with DRF non-GLP PRELIMINARY STUDIES FOR DRUGS COMBINATION AFTER INTRAVAGINAL ADMINISTRATION

 

In connection with obtaining the grant for the project “Opracowanie  innowacyjnego leku do terapii zakażeń pochwy” (POIR.01.01.01-00-0294/17) under Measure 1.2 Sectoral R&D programmes of the Operational Programme Smart Growth 2014-2020, acting on the basis of Article 13 point 6 grant agreement, Adamed Pharma S.A. invites to submit tenders for the below-defined service.

The company stipulates that disclosure of the full details concerning the subject of contract/order will be done after signature of the confidentiality agreement (in case of contractors with whom such an  agreement have not yet been concluded), which has been attached to this inquiry (Appendix 1)

Subject of the Tender

  1. GLP COMPLIANT TOXICOLOGY studies in the dogs with DRF non-GLP preliminary studies for small molecular anti-infective intravaginal drugs combination with measurement of pharmacokinetics parameters and local tolerance endpoints in living organisms. Performing a IND/CTA-enabling package of non-clinical toxicology studies in compliance with International Conference on Harmonisation (ICH) and European Medicines Agency (EMA) guidelines.

The Order contains below stated elements.

  1. Development in accordance with the Terms of Reference and accepted by the Contracting Authority of a protocol and study schedule of non-clinical studies that are the object of this order.
  2. Performing a non-GLP, single dose, dose-escalation study for drug combination to determine the Maximum Feasible Dose (MFD) in dog. Analyses and interpretation of toxicokinetics and toxicology data.
  3. Performing a non-GLP, repeated-dose Dose Range Finding (DRF) toxicology study of tested drugs combination after vaginal administration to dogs. Analysis and interpretation of toxicokinetics and toxicology data. Study plan should be prepared by the Tenderer.
  4. Performing a 28-day repeated-dose OECD GLP toxicology study in dogs with 28-day recovery period. Study performed in compliance with EMA guidelines, in particular: ICH M3(R2), EMA/CHMP/SWP/2145/2000 Rev. 1, Corr. 1* and CPMP/SWP/1042/99 Rev 1 Corr. Quantitative bioanalytical analysis of tested drugs concentrations in plasma. Statistical analyses and interpretation of toxicokinetics and toxicology data. Local tolerance endpoints included. Study plan should be prepared by the Tenderer.
  5. Development and validation of High-Performance Liquid Chromatography (HPLC) methods to measure the concentration of tested drugs (2) in the OECD GLP standard.
  6. Development and validation of liquid chromatography–mass spectrometry (LC-MS/MS) methods to measure the concentration of tested drugs (2) in dogs plasma in the OECD GLP standard.
  7. Management of the study with preparation of final audited report from experiments containing toxicological assessment of compound, statistical analysis and raw data, in English, both paper and electronic version in format adjusted to eCTD.

  2. Place of delivery: Adamed Pharma SA, Pieńków, Mariana Adamkiewicza 6A, 05-152 Czosnów

  3. It is allowed to introduce small changes by Contracting Authority in the order regarding number of animals in  groups, dosage and scope of experiments, however the order will not extend the frames of this request for proposal.

  4. The contracting Party is allow to order GLP studies separately (d).

  5. All above mentioned tasks should be priced accordingly to Appendix 3 in the offer.

Conditions for participation in the proceedings:

  1. Orders cannot be awarded to entities affiliated personally of financially with the Contracting Authority. Through financial or personal connection, we understand the interactions between the Contracting Authority or persons authorized to enter into commitments on behalf of the Contracting Authority or persons performing on behalf of the Contracting Party activities associated with the preparation and the procedure for selecting Suppliers and Supplier, in particular by:
    • participation in the company as a partner or partnership,
    • owning at least 10% of the shares,
    • the functions of a member of the supervisory or management, proxy,
    • remaining married in consanguinity or affinity in a straight line, second-degree consanguinity or affinity of the second degree in the collateral line or by adoption or guardianship.

In order to fulfill this condition a tenderer is obliged to send with the offer signed statements about the lack of connections (Appendix 4).

  1. This offer is addressed to entities having an experience in realization of similar services. Experience should be demonstrated by submission of appropriate documents.
  1. The contractor must have at least 5 years’ documented experience in studies on pharmaceuticals in the scope of ADME/PK, toxicology and legal regulations applicable in this scope. The mentioned experience should be documented in proposal or statement of experience should be provided (Appendix 5)
  2. The Tenderer should demonstrate that it has all resources to provide services in non-GLP and GLP regulatory toxicology studies by submitting the list of infrastructural and personnel resources with a short description of works carried out with their involvement (Appendix 6)
  3. Contractor must have a GLP recognition certificate from an OECD authorized monitoring authority. The copy of certificate should be provided by the Contractor (Appendix 7)
  4. The contractor/subcontractor that performs experiments on animals must have a full AAALAC accreditation issued by Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International Council that guarantees application of 3R’s practice (Replacement, Reduction and Refinement). The copy of certificate should be provided by the Contractor (Appendix 8)
  5. The analytics facility must have the OECD GLP certificate as well as experience in measurement of drug concentration using LC-MS/MS in dog plasma, what should be stated in the offer. The copy of certificate as well as references, opinions or statement of experience should be provided by the Contractor (Appendix 9).
  6. The contractor should use a quality management system and the auditing system to ensure compliance with all required regulatory requirements. The copy of certificate should be provided by the Contractor (Appendix 10)
  7. Include Contactor’s Curriculum Vitaes of the principle team members, in particular a Study Director and toxicologist with highlighted experience in the field of formal preclinical development and regulatory expertise on toxicology of at least 7 years, including at least five in GLP studies conducted. (Appendix 11)

Terms and methods of offer submission

  1. The title of each correspondence should include the number of the procedure RFP 12564 - Company name -
  2. Offers should be received by 13th of November 2019, 11:59 p.m.

Questions of the inquiry:

The deadline for submitting the questions for the inquiry to 20th of October 2019, until 10:00 CET

Answers to your questions should be sent within 25th of October 2019, by the end of the day.

Questions should be submitted in the form of a completed Appendix No. 12.

In order to ensure equal access to information to all Tenderers participating in the proceedings, questions and answers (with hiding the author's questions) will be sent to all Tenderers .

  1. Any Supplier may submit only one offer.
  2. Partial bids are not
  3. Offer along with the required attachments, must be submitted email address: stojak@adamed.com.
  4. The offer should be prepared on the excel spreadsheet, which constitutes an Appendix 3 to this offer: In addition, the Supplier may prepare the offer in its format. If Appendix 3 is not filled in, the offer will not be taken into consideration

In addition, the Bidder may also prepare an offer in his own preferable format

  1. Supplier's Offer should be comprehensive in Polish or English, electronically.
  2. The offer should include at least the following information: supplier name and address, bid inquiry number, price (PLN/EUR), delivery date (time required for delivery in days), date of payment.
  3. The offer should be prepared on the excel spreadsheet, which constitutes an Appendix 11 to this offer: In addition, the Supplier may prepare the offer in its format. If Appendix 9 is not filled in, the offer will not be taken into consideration.
  4. The offer should include all required Appendices, i.e. Appendix 1-11 - please use the attached checklist (Appendix 12) to confirm that all required documents will be delivered
  5. If the prices in the offer are expressed in EUR, they will be converted using the exchange rate of 4,3117 PLN / EUR, in accordance with the Ordinance of the Prime Minister of 28 December 2017 on the average exchange rate of the Polish zloty against the euro as the basis for conversion of the value of public contracts.
  6. In the case of another currency, the average NBP exchange rate from the last day of submitting offers will be accepted for conversion.
  7. Tenders submitted after the deadline will not be considered.
  8. The Supplier before time-limit for receipt of tenders is entitled:
    • to withdraw the offer by written notification by e-mail indicated for the submission of tenders,
    • to change the offer – notification of the changes must be submitted by the same rules as the submitted offer, appropriately marked with the note "CHANGING THE OFFER".

Selection criteria and evaluation methods:

  1. The Contracting Authority is entitled to reject the tender submitted by the Supplier who does not meet the conditions for participation in the proceedings, or if the offer is incomplete or incompatible with this request.
  2. Selection criteria:
    • Net price (PLN/EUR), the weight criterion - 60%, shall include all the associated costs.
    • Delivery time (declared time needed for delivery of the final report in weeks) - 40% of the overall assessment.
  3. The Contracting Authority shall evaluate offers based on the result of the accumulated number of points calculated on the basis of above criteria and scores:

Criteria

Weight criterion [%]

Method of evaluation in accordance with the formula

Price

60%

net price of the lowest offer/net price of tested offer x 100 x 60 % = number of points,

Delivery time

40%

the shortest time / offer tested x 100 x 40% = number of points

 

  1. The amounts of points for each criterion after summing up will be the final number of points awarded by each tender. As the most advantageous offer will be considered that which obtains the highest number of points.
  2. The results of the mathematical calculations carried out in the evaluation of tenders are rounded to the second decimal place. In case of equal scores for at least two offers the Contracting Authority will make the final choice of the offer more favorable when it comes to the impact on the environment (including the number of laboratory animals planned to use). For this purpose, the Contracting Authority shall have the right to call the Suppliers, whose tenders have obtained the highest final points, to complete the offer by giving indicated by the Contracting Authority information about an impact of the offer on the environment. The deadline to complete the offer will be determined by the Contracting Authority, but it cannot be less than 3 working days from receipt of the request.

General provisions

  1. The Contracting Authority reserves the right to terminate the procedure at each stage without giving any reason.
  2. In the case of cancellation of the contract the Suppliers are not entitled to claim for reimbursement of the costs of participation in the proceedings.
  3. Submission of the application for registration in the process or tender is implies acceptance without reservation all the conditions of the proceedings.
  4. Withdrawal by the Contracting Authority from the conclusion of the contract after the notification the Supplier about the selecting the offer, cannot be the basis for claims of incurred costs of participation in the proceedings.
  5. In the process of evaluating Offers the Contracting Authority may seek information from the contractors concerning the content of their documents.
  6. If the application does not contain all the required elements, the Contracting Authority may in justified cases call the Supplier to complete it.
  7. The Contracting Authority reserves the right to record sound during technical meetings with suppliers. Submission of the offer will be treated as giving consent to the recording of the meeting.
  8. The Contracting Authority allows negotiations of the contract terms and conditions with the bidder.
  9. The Contracting Authority reserves the right to negotiate the proposal with the bidder, whose bid has the highest number of points, especially when the price offered by the bidder exceeds the budget intended by the Contracting Authority to perform the order. Negotiations may have several consecutive  rounds  with  the  possibility  to  invite  bidder  to  submit  the updated quotation after each round of negotiations
  10. Terms of contract change: The contracting authority envisages the possibility of introducing significant changes to the contract concluded as a result of the conducted contract award procedure in relation to the content of the offer, on the basis of which the contractor was selected, in the event of the necessity to change the indicated scope of works specified in the offer:
    • Necessary or justified changes in the design documentation resulting from unforeseeable reasons,
    • The necessity or the technical-economic appropriateness of the use of equivalent materials and equipment,
    • The necessity to make equivalent solutions resulting from technological or utility conditions,
    • Financial constraints on the part of the Contracting Authority which cause the necessity to limit the scope of works included in the offer,
    • Necessary or justified changes in the delivery time and conditions of the contract subject resulting from unforeseeable reasons
    • Any changes and additions to the contract concluded with the selected Supplier will be made in the form of written annexes to the contract signed by both parties, under rigor of invalidity.

Cooperation and communication

  1. Any questions should be submitted by email: aleksandra.stojak@adamed.com
  2. Answers will be provided to all the participants via by email: stojak@adamed.com.
  3. The person authorized to contact the bidders (Monday-Friday between 09:00-17:00) is:Aleksandra.stojak@adamed.com

Significant agreement conditions

1. “IP Rights” means all intangible, intellectual, proprietary and industrial property rights and all intangible embodiments thereof wherever located with respect to the particular R&D, including without limitation, (i) all trade-marks, trade names, slogans, domain names, URLs or logos; (ii) all copyrights, moral rights and other rights in works of authorship; (iii) all patents and patent applications, industrial designs, patentable ideas, inventions and innovations; (iv) all know-how and trade secrets; and (v) all registrations, applications, renewals, extensions, continuations, divisions or reissues thereof now or hereafter in force (including any rights in any of the foregoing); (vi) all results of research, i.e. data and reports, samples and chemical or biological products;

2. “Contracting Authority Own IP” means all intangible, intellectual, proprietary and industrial property rights and all intangible embodiments thereof wherever located which are the possession of the Contracting Authority and are furnished to the Supplier by the Contracting Authority in connection with the Supplier’s prosecution of R&D hereunder, including without limitation, (i) all trade-marks, trade names, slogans, domain names, URLs or logos; (ii) all copyrights, moral rights and other rights in works of authorship; (iii) all patents and patent applications, industrial designs, patentable ideas, inventions and innovations; (iv) all know-how and trade secrets; and (v) all registrations, applications, renewals, extensions, continuations, divisions or reissues thereof now or hereafter in force (including any rights in any of the foregoing); (vi) all results, data and reports;

3. “Confidential Information” means all information disclosed by one Party to the other, regardless of the form of disclosure (except anything that is expressly designated as non-confidential), and will include without limitation (i) all information relating to research, development, technologies, markets, products, patents, inventions, procedures, methods, designs, data, programs and improvements; and (ii) the terms and existence of the Agreement and the relationship of the Parties to one another; but will not include any information that:

  1. was provided to the receiving Party under no duty of confidentiality to the disclosing Party; or
  2. is or becomes public domain through no fault or act of the receiving Party;
  3. was independently developed by the receiving Party without the use of or reliance on the disclosing Party’s Confidential Information;
  4. is required to be disclosed by applicable law, provided, however, that prompt prior notice thereof will be given to the Party whose Confidential Information is to be disclosed and the receiving Party uses reasonable efforts to obtain a protective order limiting the further use or disclosure of such information.

4. “Developed method” means any method developed as a result of R&D, including in particular, but not limited to support in preclinical development.

5. “Supplier’s Own Technical Information” means any technical information relating to the Supplier’s services performed hereunder including, but not limited to, the Supplier’s methods and materials used and created before the performance of R&D, and also includes all business, legal and financial information relating to the Supplier.

6. [Contract’s value] Estimated total value of the contract during the term of the Project: [to be filled] PLN (net). It is allowed to grant supplementary orders to the selected Bidder, only if are consistent with the primary purpose of this contract, in the amount not exceeding 50% of the value of this order.

The proposal/quotation shall include all the associated costs (e.g. raw materials, additional services, licenses etc.).

7. [Framework agreement] The Contracting Authority upon settlement of the subject of the proceedings will conclude a framework agreement with selected suppliers (“The Agreement”). The aim of the procedure is to establish the terms governing contracts which may be implemented by the Purchaser during the term of the framework agreement, in particular the price, delivery time and the extent of ordered items in the appropriate Project Order. Under the Agreement the Contracting Authority undertakes no obligation to purchase a certain quantity of products or services from the Supplier. The Contracting Authority will purchase products or services from the Supplier only when during the term of the framework agreement, a need to acquire them will be created. Realization of deliveries will proceed on the basis of successively placed orders according to the current needs of the Purchaser.

8. “Service” The Contracting Authority employs the Supplier to prosecute, and provide the results arising therefrom, the particular R&D, as required by the Contracting Authority, to the Contracting Authority, along with all IP Rights arising therefrom.

9. “Third Party Performer” The Supplier may enter into particular service agreements with various Third Party Performers of R&D such that the particular R&D or a portion thereof required by the Contracting Authority may be performed by said Third Party Performers, provided that the Supplier shall be fully liable for the Third Party Performer’s actions or omissions as though for its own actions or omissions.

10. [Deliverables] Delivery of the order will be executed at the expense of the Supplier to the Contracting Authority, on whose behalf the order will consist of designated persons. It is not required to sign a confirmation order delivery. The person will make confirmation of receipt electronically using the Adamed Procurement System.

11. [Offer’s parameters] The Purchaser requires other important parameters of the offer:

11.1. Payment deadline: minimum 45 days;

11.2. The validity of the offer: 90 days;

11.3. The price guarantee: minimum 12 months from the contract date.

12. [Intellectual Property] Under the Agreement the Contracting Authority exclusively acquires from the Supplier or any Third Party Performer any rights to results, data, information, discoveries, technology or inventions created, generated, made, conceived, developed, or reduced to practice, as well as the accompanying documentation, including in particular, but not limited to intellectual property rights (full copyrights, including any derivative rights, industrial property rights or know-how and trade secrets) to Developed Methods and to accompanying documentation, as part of or in connection with the performance R&D, once the IP Rights comes into existence. The Contracting Authority shall have the right to use such IP Rights for any and all purposes, and shall have the full, unrestricted right to assign, license or otherwise transfer any such IP Rights and the deliverables without any further payment to the Supplier. The remuneration for sale and assignment of the IP Rights is included in the amount that the Contracting Authority agrees to pay the Supplier as described in a specific Project Order.

IP Rights of the Supplier or the Third Party Performer, including industrial property and know-how, necessary to complete the Project Orders and created before the performance of the Agreement started (“Background IP”) applied during the performance of R&D activities, shall remain the property of the Supplier or the Third Party Performer. To the extent necessary for the Supplier to duly execute the Project Orders and for the Contracting Authority to use the possibilities arising from their execution, the Supplier or the Third Party Performer shall provide the Contracting Authority with relevant licenses and permits for the Background IP, in particular relevant licenses and permits for using methods developed as a result of Project Orders.

The Supplier and the Third Party Performer are not entitled to submit any applications in order to protect the IP rights, including, but not limited to patent applications and submissions concerning other exclusive rights.

The Supplier shall be liable towards the Contracting Authority for ensuring that neither Third Party Performer nor any other persons involved in the performance of the Agreement on the part of the Supplier shall claim from the Contracting Authority or other third parties any remuneration in respect of such participation, including, without limitation the remuneration in respect of the creation, use or assignment of IP Rights.

Excluding any IP rights to Developed Methods and to accompanying documentation, all IP Rights in and to (i) any of the Supplier’s Own Technical Information relating to the particular R&D, (ii) all know-how, trade secrets, methods and data related thereto, (iii) all improvements to and new uses of, and new techniques and methods used to apply the Supplier’s Own Technical Information relating to the particular R&D, developed during or resulting from the performance of the particular R&D, shall remain the exclusive property of the Supplier.

13. [Confidential Information] Neither Party shall disclose the other Party’s Confidential Information to any third party without such Party’s express prior written authorization. Each Party will only disclose the other Party’s Confidential Information to its directors, officers, or employees who have a direct need to obtain such Confidential Information to fulfill the Party’s obligations under the Agreement, and then, only to the extent necessary for such directors, officers, or employees to do so, always provided that the scope of such disclosure conforms with the scope of tasks assigned to such persons in connection with the Agreement and that such persons are informed by the Contracting Authority about the obligations resulting from the Agreement and obliged to abide by all confidential information obligations, including but not limited to keeping the Confidential Information strictly confidential and not using the Confidential Information in any manner other than permitted by the Agreement.

The Supplier undertakes to ensure that any service agreement entered in to with a Third Party Performer for the performance of certain R&D shall be accompanied by a non-disclosure agreement so as to protect Confidential Information.

14. [Order Acceptance Certificate] Within ten (10) business days from the Contracting Authority’s receipt of the report and any other deliverables ordered, the Parties shall sign an acceptance certificate.

15. [Inconsistencies or defects] If there are material inconsistencies or defects in the execution of the Services due to the sole fault of the Supplier, the Supplier shall be obligated to repeat the inconsistent Services at its own costs. Objections to test results must be made by the Contracting Authority to the Supplier within fourteen (14) business days after the Supplier receives the final Report and the Contracting Authority shall specify in reasonable detail material inconsistencies or defects. These works should be carried out without undue delay and the period for the collection of Materials stated in the relevant Project Order shall be extended accordingly. Subject to that the Supplier would not be able to re-perform the Services free of such inconsistencies, the Supplier shall refund the monies paid for such services if inconsistencies are found.

16. [Audit] The Contracting Authority reserves the right to audit the Supplier before the conclusion of the contract or in the course of its duration.

17. [Penalty clause] The Supplier shall pay penalty clauses:

17.1. a delay in the delivery date of the order for each day of delay, if the delay is not the fault of the Contracting Authority,

17.2. due to improper execution of the contract,

17.3. due to incomplete execution of the contract.

The Supplier agrees to deduct the amount of liquidated damages directly at the payment of VAT invoice on delivery.

18. [Supplier’s indemnification] The Supplier will indemnify, defend, and hold the Contracting Authority harmless from and against any and all liability, losses (including reasonable attorneys’ fees) or damages they may suffer (including as a result of claims, demands, costs or judgments against them) from third party claims (collectively, “Losses”) that arise out of (a) the negligence or willful misconduct of The Supplier or any of its employees, consultants or subcontractors, including without limitation any Third Party Performer (b) the failure of the Supplier or any of its employees, consultants or subcontractors to comply with the Contracting Authority written instructions, or (c) the material breach of the Agreement or any Project Order by the Supplier, except to the extent that any such Losses are caused by (a) the negligence or willful misconduct of the Contracting Authority, (b) the Contracting Authority use of the IP Rights generated from the services of the Supplier, or (c) the material breach of the Agreement or any Project Order by the Supplier.

19. [The Contracting Authority’s indemnification] The Contracting Authority will indemnify, defend, and hold the Supplier harmless from and against any and all liability, losses (including reasonable attorneys’ fees) or damages they may suffer (including as a result of claims, demands, costs or judgments against them) from third party claims (collectively, “Losses”) that arise out of (a) the negligence or willful misconduct of the Contracting Authority or any of its employees, consultants or subcontractors, (b) a subject alleging injury/illness sustained as a result of the subject’s participation in the Contracting Authority clinical study involving the administration of the Contracting Authority drug, (c) the Contracting Authority use of IP generated from the services of the Supplier, or (d) the material breach of the Agreement or any Project Order by the Contracting Authority, except to the extent that any such Losses are caused by (a) the negligence or willful misconduct of the Supplier, including without limitation any Third Party Performer (b) the failure of the Supplier or any of its employees, consultants or subcontractors, including without limitation any Third Party Performer to comply with the Contracting Authority’s written instructions, or (c) the material breach of the Agreement or any Project Order by the Supplier, including without limitation any Third Party Performer.

20. [Offer’s costs] The Supplier carries all costs associated with preparing and submitting the offer. Contracting Authority does not provide for reimbursement of the costs of participation in the proceedings.

21. [Effective date] The Agreement will commence on (a) the Effective Date (date of the last signature) and shall expire on 12.2020 or (b) the completion of all Services under the last Project Order executed by the parties prior to 31.12.2020. The Term may be extended by mutual written agreement of the Parties.

22. [Governing law] Agreement may be construed and enforced in accordance with, and the rights of the parties shall be governed by, the laws of the Parties choice.

General provisions

1. The Contracting Authority reserves the right to terminate the procedure at each stage without giving any reason.

2. In the case of cancellation of the contract the Suppliers are not entitled to claim for reimbursement of the costs of participation in the proceedings.

3. Submission of the application for registration in the process or tender is implies acceptance without reservation all the conditions of the proceedings.

4. Withdrawal by the Contracting Authority from the conclusion of the contract after the notification the Supplier about the selecting the offer, cannot be the basis for claims of incurred costs of participation in the proceedings.

5. In the process of evaluating Offers the Contracting Authority may seek information from the contractors concerning the content of their documents.

6. If the application does not contain all the required elements, the Contracting Authority may in justified cases call the Supplier to complete it.

7. The Contracting Authority reserves the right to record sound during technical meetings with suppliers. Submission of the offer will be treated as giving consent to the recording of the meeting.

8. The Contracting Authority allows negotiations of the contract terms and conditions with the bidder.

9. The Contracting Authority reserves the right to negotiate the proposal with the bidder, whose bid has the highest number of points, especially when the price offered by the bidder exceeds the budget intended by the Contracting Authority to perform the order. Negotiations may have several consecutive  rounds  with  the  possibility  to  invite  bidder  to  submit  the updated quotation after each round of negotiations

10. Terms of contract change: The contracting authority envisages the possibility of introducing significant changes to the contract concluded as a result of the conducted contract award procedure in relation to the content of the offer, on the basis of which the contractor was selected, in the event of the necessity to change the indicated scope of works specified in the offer:

10.1. Necessary or justified changes in the design documentation resulting from unforeseeable reasons,

10.2. The necessity or the technical-economic appropriateness of the use of equivalent materials and equipment,

10.3. The necessity to make equivalent solutions resulting from technological or utility conditions,

10.4. Financial constraints on the part of the Contracting Authority which cause the necessity to limit the scope of works included in the offer,

10.5. Necessary or justified changes in the delivery time and conditions of the contract subject resulting from unforeseeable reasons

10.6. Any changes and additions to the contract concluded with the selected Supplier will be made in the form of written annexes to the contract signed by both parties, under rigor of invalidity.

Cooperation and communication

  1. The person authorized to contact the bidders (Monday-Friday between 09:00-17:00) is: Aleksandra Stojak [aleksandra.stojak(at)adamed.com

 Appendix 3 Proposal (dowlonad)

 Appendix 3 Statement (dowlonad)

 Appendix 12 (dowlonad)

 Appendix 13 (dowlonad)